ࡱ> ikh bjbj .fxx1111$U41F|||0222222$DV|<@|||VkTTT|"0T|0TTT@rzX41 T0TTT||T|||||VVT|||||||||||||||| :  SEQ CHAPTER \h \r 1 Cape Breton University Animal Use Protocol ANIMAL CARE COMMITTEE  Schedule 12 - BREEDING COLONIES/GENETICALLY MODIFIED ANIMALS Section I. Species:Strain:Source of Animals (please specify if derived on site, donated, purchased from commercial supplier, etc.):Are the animals being used as part of a breeding colony?yes [ ] no [ ] An affirmative answer requires the completion of Section II.Are these animals genetically modified?yes [ ] no [ ] An affirmative answer requires the completion of Section III.Is biological containment required?yes [ ] no [ ] An affirmative answer requires the completion of Section IV.Section II.(a) Are the animals available from a commercial supplier?yes [ ] no [ ]If yes, why is it necessary to breed animals at Cape Breton University?(b) Name of person managing the colony:Telephone NumberFAXE-Mail(c) Approximately how many female breeders will be needed in one year?(d) Approximately how many male breeders will be needed in one year?(e) Approximately how many offspring will be produced in one year?(f) How does this relate to your anticipated use?(g) If more animals are produced than required for your experimental protocol(s), what happens to the excess animals?(h) Will the animals produced be used in protocols other than this one?yes [ ] no [ ]If yes, list all the protocols:Section III.(a) List and describe the genetic alterations to be induced or which have been characterized in the animal model you are using.(b) What known traits will affect breeding and/or lifespan?(c) Describe the expected phenotypic expression of the alterations.(d) If morbidity develops due to genetic alteration, please describe steps to be taken to reduce pain and distress to the animals.(e) What criteria will be used for early removal from the study or euthanasia of animals?Section IV. 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